Systemic Lupus Erythematosus - SLE

---females
---14-45 years
--- fever, fatigue, weight loss
--- malar rash, photosensitivity, discoid lupus

--- pleural effusion, pneumonitis, pulmonary hypertension, interstitial lung disease

--- neurologic disorders

--- oropharyngeal ulcers

--- photosensitivity

--- arthritis

--- hematologic disorder

--- Libman-Sacks endocarditis
sterile vagetations, verrucous, wart-like

--- hilar adenopathy

--- Raynaud's phenomenon

--- nephritic syndrome
--- false-positive on Syphilis test (RPR-VDRL) due to antiphospholipid ABs that cross-react with cardiolipin used in tests.
--- ANA
--- anti-dsDNA (very specific and poor prognosis)
--- anti-Smith ABs (very specific, not prognostic)
--- antihistone antibodies - drug-induced lupus
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