Polymyositis

----progressive symmetrical muscle weakness --- painless
---- gradually develop (3-5 months)
---- CD8+ T-cell -induced injury to myofibers
---- SHOULDERS  - most commonly involved

---- loss of muscle mass
---- multiple muscles are involved
---- dysphagia and aspiration
---- cardiac involvement
---- pelvic girdle involvement
---- because this is a systemic disiease:

• Morning stiffness
• Fatigue
• Anorexia
• Fever
• Weight loss
  
  
  
  
  Drug-induced myopathy may result from the following:

  • Alcohol
  • Antimalarials
  • Clofibrate
  • Colchicine
  • Ketoconazole and other azole antifungal agents
  • Statin/3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
  • D-penicillamine
  • Vincristine
  • Zidovudine (AZT)