Hereditary angioedema

--- low serum levels of C1 esterase inhibitor

---aut-Dom or acquired (treatment with ACE inhibitors)

--episodes of painless, non-pitting, well-circumscribe edema of the face, neck, lips,tongue, and also internal organs (tracheobrachial tree, GI,)

Do not use ACE inhibitors in patients with hereditary angioedema.