Biologic Actions of Growth Hormone

        1) Heart, Lungs, Bones

• increases protein synthesis
• increases RNA synthesis
• increases DNA synthesis
• increases cell size & numbers
• increases organ size

          2) Chondrocytes

• increases Linear growth
• increases cell size & numbers
• increases chondroitin sulfate
• increases collagen
• increases RNA synthesis
• increases DNA synthesis
• increases protein synthesis
• increases amino acid uptake

          3) Muscles

• increases lean body mass
• increases protein synhtesis
• increases amino acid uptake
• decreases glucose uptake

       4) Liver

• increases RNA synthesis
• increases protein synthesis
• increases gluconeogenesis
• increases IGFBP & IGFs

        5) Adipose tissue

• increases Lipolysis
• decreases adiposity
• decreases glucose uptake