X-linked or aut-recess
Defects in genes coding components of NADPH oxidase.
Myeloperoxidase-halide system is necessary for neutrophils to fight against bacteria.
Myeloperoxidase-halide system need H2O2 to function, which is produced by bacterial metabolism and by NADPH oxidase.
Catalase + bacteria can destroy the H2O2.
So..
NO NADPH oxidase. =====>. NO H2O2 =====> catalase + bacteria stay alive. ====>>>>> marked susceptibility to such infections: E.coli, St. aureus, Serattia, Aspergillus
Negative nitroblue tetrazolium dye reduction test
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